1s9l
From Proteopedia
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| - | [[Image:1s9l.jpg|left|200px]] | + | [[Image:1s9l.jpg|left|200px]] |
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| - | '''NMR Solution Structure of a Parallel LNA Quadruplex''' | + | {{Structure |
| + | |PDB= 1s9l |SIZE=350|CAPTION= <scene name='initialview01'>1s9l</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''NMR Solution Structure of a Parallel LNA Quadruplex''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1S9L is a [ | + | 1S9L is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA]. |
==Reference== | ==Reference== | ||
| - | NMR solution structure of a parallel LNA quadruplex., Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L, Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:[http:// | + | NMR solution structure of a parallel LNA quadruplex., Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L, Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15181173 15181173] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Esposito, V.]] | [[Category: Esposito, V.]] | ||
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[[Category: quadruplex]] | [[Category: quadruplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:02:12 2008'' |
Revision as of 12:02, 20 March 2008
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NMR Solution Structure of a Parallel LNA Quadruplex
Overview
The solution structure of a locked nucleic acid (LNA) quadruplex, formed by the oligomer d(TGGGT), containing only conformationally restricted LNA residues is reported. NMR and CD spectroscopy, as well as molecular dynamics and mechanic calculations, has been used to characterize the complex. The molecule adopts a parallel stranded conformation with a 4-fold rotational symmetry, showing a right-handed helicity and the guanine residues in an almost planar conformation with three well-defined G-tetrads. The thermal stability of Q-LNA has been found to be comparable with that of [r(UGGGU)]4, while a T(m) increment of 20 degrees C with respect to the corresponding DNA quadruplex structure [d(TGGGT)]4 has been observed. The structural features of the LNA quadruplex reported here may open new perspectives for the biological application of LNAs as novel versatile tools to design aptamer or catalyst oligonucleotides.
About this Structure
1S9L is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR solution structure of a parallel LNA quadruplex., Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L, Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:15181173
Page seeded by OCA on Thu Mar 20 14:02:12 2008
