1s9s

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[[Image:1s9s.gif|left|200px]]<br /><applet load="1s9s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1s9s.gif|left|200px]]
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caption="1s9s" />
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'''SOLUTION STRUCTURE OF MLV PSI SITE'''<br />
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{{Structure
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|PDB= 1s9s |SIZE=350|CAPTION= <scene name='initialview01'>1s9s</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''SOLUTION STRUCTURE OF MLV PSI SITE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1S9S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9S OCA].
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1S9S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9S OCA].
==Reference==
==Reference==
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NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus., D'Souza V, Dey A, Habib D, Summers MF, J Mol Biol. 2004 Mar 19;337(2):427-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15003457 15003457]
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NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus., D'Souza V, Dey A, Habib D, Summers MF, J Mol Biol. 2004 Mar 19;337(2):427-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15003457 15003457]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Dey, A.]]
[[Category: Dey, A.]]
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[[Category: u-u mismatch]]
[[Category: u-u mismatch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:02:11 2008''

Revision as of 12:02, 20 March 2008

Image:1s9s.gif


PDB ID 1s9s

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Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF MLV PSI SITE


Overview

The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a "core encapsidation signal" that is essential for efficient genome packaging during virus assembly. We have determined the structure of a 101-nucleotide RNA that contains this signal (called mPsi) using a novel isotope-edited NMR approach. The method is robust and should be generally applicable to larger RNAs. mPsi folds into three stem loops, two of which (SL-C and SL-D) co-stack to form an extended helix. The third stem loop (SL-B) is connected to SL-C by a flexible, four-nucleotide linker. The structure contains five mismatched base-pairs, an unusual C.CG base-triple platform, and a novel "A-minor K-turn," in which unpaired adenosine bases A340 and A341 of a GGAA bulge pack in the minor groove of a proximal stem, and a bulged distal uridine (U319) forms a hydrogen bond with the phosphodiester of A341. Phylogenetic analyses indicate that these essential structural elements are conserved among the murine C-type retroviruses.

About this Structure

1S9S is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus., D'Souza V, Dey A, Habib D, Summers MF, J Mol Biol. 2004 Mar 19;337(2):427-42. PMID:15003457

Page seeded by OCA on Thu Mar 20 14:02:11 2008

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