1sbu
From Proteopedia
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| - | [[Image:1sbu.gif|left|200px]] | + | [[Image:1sbu.gif|left|200px]] |
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| - | '''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2''' | + | {{Structure |
| + | |PDB= 1sbu |SIZE=350|CAPTION= <scene name='initialview01'>1sbu</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SBU is a [ | + | 1SBU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA]. |
==Reference== | ==Reference== | ||
| - | A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:[http:// | + | A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15326523 15326523] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Chierici, S.]] | [[Category: Chierici, S.]] | ||
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[[Category: cis leu-(dmt)thiazolidine amide bond]] | [[Category: cis leu-(dmt)thiazolidine amide bond]] | ||
[[Category: dimethyl-thiazolidine]] | [[Category: dimethyl-thiazolidine]] | ||
| - | [[Category: molecular dynamics | + | [[Category: molecular dynamics simulation]] |
[[Category: nmr spectroscopy]] | [[Category: nmr spectroscopy]] | ||
[[Category: vi beta turn]] | [[Category: vi beta turn]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:02:59 2008'' |
Revision as of 12:03, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2
Overview
The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
About this Structure
1SBU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:15326523
Page seeded by OCA on Thu Mar 20 14:02:59 2008
