4hkf

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[[Image:4hkf.jpg|left|200px]]
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==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
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<StructureSection load='4hkf' size='340' side='right' caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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{{STRUCTURE_4hkf| PDB=4hkf | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
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===Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA===
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atat1, mec17, si:ch211-152p11.5, zgc:65893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
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==About this Structure==
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-tubulin_N-acetyltransferase Alpha-tubulin N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.108 2.3.1.108] </span></td></tr>
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[[4hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [http://www.ebi.ac.uk/pdbsum/4hkf PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Alpha-tubulin N-acetyltransferase]]
[[Category: Alpha-tubulin N-acetyltransferase]]
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Ding, J.]]
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[[Category: Ding, J]]
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[[Category: Li, W.]]
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[[Category: Li, W]]
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[[Category: Sun, B.]]
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[[Category: Sun, B]]
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[[Category: Xu, S.]]
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[[Category: Xu, S]]
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[[Category: Zhang, T.]]
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[[Category: Zhang, T]]
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[[Category: Zhong, C.]]
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[[Category: Zhong, C]]
[[Category: Acetyl-coa]]
[[Category: Acetyl-coa]]
[[Category: Gnat]]
[[Category: Gnat]]

Revision as of 15:30, 25 December 2014

Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA

4hkf, resolution 1.70Å

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