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3v1w
From Proteopedia
(Difference between revisions)
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| - | + | ==Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin== | |
| - | + | <StructureSection load='3v1w' size='340' side='right' caption='[[3v1w]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3v1w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V1W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v1w RCSB], [http://www.ebi.ac.uk/pdbsum/3v1w PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | == | + | == Function == |
| - | [[3v1w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1W OCA]. | + | [[http://www.uniprot.org/uniprot/CASQ1_RABIT CASQ1_RABIT]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: Kang, C | + | [[Category: Kang, C]] |
| - | [[Category: Lewis, K M | + | [[Category: Lewis, K M]] |
| - | [[Category: Muralidharan, A K | + | [[Category: Muralidharan, A K]] |
| - | [[Category: Nissen, M N | + | [[Category: Nissen, M N]] |
| - | [[Category: Sanchez, E J | + | [[Category: Sanchez, E J]] |
| - | [[Category: Subramanian, A K | + | [[Category: Subramanian, A K]] |
[[Category: Calcium binding protein]] | [[Category: Calcium binding protein]] | ||
[[Category: Thioredoxin fold]] | [[Category: Thioredoxin fold]] | ||
Revision as of 02:48, 25 December 2014
Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin
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