4bac
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==prototype foamy virus strand transfer complexes on product DNA== |
| + | <StructureSection load='4bac' size='340' side='right' caption='[[4bac]], [[Resolution|resolution]] 3.26Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4bac]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_spumaretrovirus Human spumaretrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BAC FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x6n|2x6n]], [[2x6s|2x6s]], [[2x74|2x74]], [[2x78|2x78]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bac RCSB], [http://www.ebi.ac.uk/pdbsum/4bac PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Integrase is the key enzyme that mediates integration of retroviral DNA into cellular DNA which is essential for viral replication. Inhibitors of HIV-1 that target integrase recognize the nucleoprotein complexes formed by integrase and viral DNA substrate (intasomes) rather than the free enzyme. Atomic resolution structures of HIV-1 intasomes are therefore required to understand the mechanisms of inhibition and drug resistance. To date, prototype foamy virus (PFV) is the only retrovirus for which such structures have been determined. We show that PFV Strand Transfer Complexes (STC) can be assembled on product DNA without going through the normal forward reaction pathway. The finding that a retroviral STC can be assembled in this way may provide a powerful tool to alleviate the obstacles that impede structural studies of nucleoprotein intermediates in HIV-1 DNA integration. | ||
| - | + | Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration.,Yin Z, Lapkouski M, Yang W, Craigie R Protein Sci. 2012 Sep 25. doi: 10.1002/pro.2166. PMID:23011895<ref>PMID:23011895</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Human spumaretrovirus]] | [[Category: Human spumaretrovirus]] | ||
| - | [[Category: Craigie, R | + | [[Category: Craigie, R]] |
| - | [[Category: Lapkouski, M | + | [[Category: Lapkouski, M]] |
| - | [[Category: Yang, W | + | [[Category: Yang, W]] |
| - | [[Category: Yin, Z | + | [[Category: Yin, Z]] |
[[Category: Transferase-dna complex]] | [[Category: Transferase-dna complex]] | ||
Revision as of 15:54, 9 December 2014
prototype foamy virus strand transfer complexes on product DNA
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