Glutathione S-transferase
From Proteopedia
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{{STRUCTURE_1pkw| PDB=1pkw | SIZE=400| SCENE= |right|CAPTION=Human glutathione S-transferase α class complex with glutathione [[1pkw]] }} | {{STRUCTURE_1pkw| PDB=1pkw | SIZE=400| SCENE= |right|CAPTION=Human glutathione S-transferase α class complex with glutathione [[1pkw]] }} | ||
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===GST=== | ===GST=== | ||
| - | [[4hz4]] – GST – ''Actinobacillus pleuropneumoniae | + | [[4hz4]] – GST – ''Actinobacillus pleuropneumoniae''<br /> |
[[1gsb]], [[1gsc]] – rGST – rat<br /> | [[1gsb]], [[1gsc]] – rGST – rat<br /> | ||
| - | [[3ubk]] – LiGST – Leptospira interrogans<br /> | + | [[3ubk]] – LiGST – ''Leptospira interrogans''<br /> |
| - | [[3uap]] - GST – Methylococcus capsulatus<br /> | + | [[3uap]] - GST – ''Methylococcus capsulatus''<br /> |
[[1aw9]] - cGST III – corn<br /> | [[1aw9]] - cGST III – corn<br /> | ||
| - | [[1okt]] – PfGST – Plasmodium falciparum<br /> | + | [[1okt]] – PfGST – ''Plasmodium falciparum''<br /> |
[[3fr6]] - PfGST (mutant) <br /> | [[3fr6]] - PfGST (mutant) <br /> | ||
| - | [[1tw9]] – GST - Heligmosomoides polygyrus<br /> | + | [[1tw9]] – GST - ''Heligmosomoides polygyrus''<br /> |
| - | [[1yq1]] - CeGST – Caenorhabditis elegans<br /> | + | [[1yq1]] - CeGST – ''Caenorhabditis elegans''<br /> |
| - | [[1y6e]] - SjGST – Schistosoma japonicum<br /> | + | [[1y6e]] - SjGST – ''Schistosoma japonicum''<br /> |
| - | [[2fno]], [[3lq7]] - AtGST – Agrobacterium tumefaciens<br /> | + | [[2fno]], [[3lq7]] - AtGST – ''Agrobacterium tumefaciens''<br /> |
| - | [[2on7]] – NaGST-1 – Necator americanus<br /> | + | [[2on7]] – NaGST-1 – ''Necator americanus''<br /> |
[[3erf]] - yGST II – yeast<br /> | [[3erf]] - yGST II – yeast<br /> | ||
| - | [[3f6f]] – DmGST – Drosophila melanogaster<br /> | + | [[3f6f]] – DmGST – ''Drosophila melanogaster''<br /> |
| - | [[3lxt]] - PsfGST – Pseudomonas fluorescens<br /> | + | [[3lxt]] - PsfGST – ''Pseudomonas fluorescens''<br /> |
| - | [[4eci]] - PaGST – Pseudomonas aeruginosa<br /> | + | [[4eci]] - PaGST – ''Pseudomonas aeruginosa''<br /> |
| - | [[3niv]] - GST – Legionella pneumophila<br /> | + | [[3niv]] - GST – ''Legionella pneumophila''<br /> |
| - | [[3tot]] - RsGST – Ralstonia solanacearum<br /> | + | [[3tot]] - RsGST – ''Ralstonia solanacearum''<br /> |
[[3ay8]] - siGST – silkworm<br /> | [[3ay8]] - siGST – silkworm<br /> | ||
| - | [[3uap]] - McGST – Methylococcus capsulatus | ||
===GST binary complex with GSH=== | ===GST binary complex with GSH=== | ||
| - | [[2x64]] – GST + GSH – Xylella fastidiosa<br /> | + | [[2x64]] – GST + GSH – ''Xylella fastidiosa''<br /> |
| - | [[4hz2]] - GST + GSH - Xanthobacter autotrophicus<br /> | + | [[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br /> |
[[4ecj]] - PaGST + GSH<BR /> | [[4ecj]] - PaGST + GSH<BR /> | ||
| - | [[1fhe]], [[2fhe]] - GST + GSH – Fasciola hepatica<br /> | + | [[1fhe]], [[2fhe]] - GST + GSH – ''Fasciola hepatica''<br /> |
| - | [[1pmt]], [[2pmt]] - GST + GSH – Proteus mirabilis<br /> | + | [[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br /> |
[[1m0u]], [[3gh6]] - DmGST + GSH<BR /> | [[1m0u]], [[3gh6]] - DmGST + GSH<BR /> | ||
| - | [[1oe7]], [[1oe8]] - ShGST + GSH – Schistosoma haematobium<br /> | + | [[1oe7]], [[1oe8]] - ShGST + GSH – ''Schistosoma haematobium''<br /> |
| - | [[1u3i]] - GST + GSH - Schistosoma mansoni<br /> | + | [[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br /> |
[[1oyj]] - GST + GSH - rice<br /> | [[1oyj]] - GST + GSH - rice<br /> | ||
[[1u87]] - SjGST + GSH<BR /> | [[1u87]] - SjGST + GSH<BR /> | ||
| - | [[2dsa]], [[2gdr]] - GST + GSH – Burkholderia xenovorans<br /> | + | [[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br /> |
[[2on5]] – NaGST-2 + GSH<BR /> | [[2on5]] – NaGST-2 + GSH<BR /> | ||
| - | [[2nto]] - OaGST + GSH – Ochrobactrum anthropi<br /> | + | [[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br /> |
[[2pvq]] - OaGST (mutant) + GSH<BR /> | [[2pvq]] - OaGST (mutant) + GSH<BR /> | ||
[[3ibh]] - yGST II + GSH<BR /> | [[3ibh]] - yGST II + GSH<BR /> | ||
[[3fr9]] - PfGST + GSH<BR /> | [[3fr9]] - PfGST + GSH<BR /> | ||
[[3m3m]] - PsfGST + GSH<BR /> | [[3m3m]] - PsfGST + GSH<BR /> | ||
| - | [[3lsz]] - GST + GSH – Rhodobacter sphaeroides<br /> | + | [[3lsz]] - GST + GSH – ''Rhodobacter sphaeroides''<br /> |
| - | [[3n5o]] - GST + GSH – Coccidioides immitis<br /> | + | [[3n5o]] - GST + GSH – ''Coccidioides immitis''<br /> |
[[3tou]] - RsGST + GSH<BR /> | [[3tou]] - RsGST + GSH<BR /> | ||
[[3uar]] - McGST + GSH<BR /> | [[3uar]] - McGST + GSH<BR /> | ||
| - | [[4g9h]], [[4gci]] - GST + GSH – Yersinia pestis<br /> | + | [[4g9h]], [[4gci]] - GST + GSH – ''Yersinia pestis''<br /> |
| - | [[4gf0]] - GST + GSH - Sulfitobacter | + | [[4gf0]] - GST + GSH - ''Sulfitobacter'' |
===GST binary complex=== | ===GST binary complex=== | ||
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[[2gsq]] – GST + GSH derivative – squid<br /> | [[2gsq]] – GST + GSH derivative – squid<br /> | ||
[[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]] - rGST + GSH derivative<br /> | [[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]] - rGST + GSH derivative<br /> | ||
| - | [[1gnw]] - AtGST + GSH derivative – Arabidopsis thaliana <br /> | + | [[1gnw]] - AtGST + GSH derivative – ''Arabidopsis thaliana'' <br /> |
[[1aqv]] - hGST + GSH derivative – human<br /> | [[1aqv]] - hGST + GSH derivative – human<br /> | ||
[[1gtb]], [[1gta]] - SjGST + praziquantel<br /> | [[1gtb]], [[1gta]] - SjGST + praziquantel<br /> | ||
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[[1bye]] - cGST I + herbicide <br /> | [[1bye]] - cGST I + herbicide <br /> | ||
[[1axd]] – cGST I + lactoyl-GSH<BR /> | [[1axd]] – cGST I + lactoyl-GSH<BR /> | ||
| - | [[1a0f]], [[1n2a]] - GST + GSH derivative – Eschericia coli<br /> | + | [[1a0f]], [[1n2a]] - GST + GSH derivative – ''Eschericia coli''<br /> |
| - | [[1f2e]] - GST + GSH derivative | + | [[1f2e]] - GST + GSH derivative – ''Sphingomonas paucimobilis''<br /> |
[[1mtc]] - rGST + GSH derivative<br /> | [[1mtc]] - rGST + GSH derivative<br /> | ||
[[1ua5]] - SjGST + GSH derivative<br /> | [[1ua5]] - SjGST + GSH derivative<br /> | ||
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===GST δ class=== | ===GST δ class=== | ||
| - | [[1r5a]], [[1v2a]], [[1pn9]] - GST + GSH derivative - Anopheles cracens<br /> | + | [[1r5a]], [[1v2a]], [[1pn9]] - GST + GSH derivative - ''Anopheles cracens''<br /> |
[[3ein]] - DmGST + GSH<BR /> | [[3ein]] - DmGST + GSH<BR /> | ||
[[3vk9]] - siGST | [[3vk9]] - siGST | ||
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===GST ε class=== | ===GST ε class=== | ||
| - | [[2il3]] - AgGST – Anopheles gambiae<br /> | + | [[2il3]] - AgGST – ''Anopheles gambiae''<br /> |
[[2imi]] - AgGST + GSH<BR /> | [[2imi]] - AgGST + GSH<BR /> | ||
[[2imk]] - AgGST + GSH derivative<br /> | [[2imk]] - AgGST + GSH derivative<br /> | ||
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===GST ν class=== | ===GST ν class=== | ||
| - | [[2ws2]] - GST – Haemonchus contortus | + | [[2ws2]] - GST – ''Haemonchus contortus'' |
===GST π class=== | ===GST π class=== | ||
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[[1gsy]] - mGST + GSH<BR /> | [[1gsy]] - mGST + GSH<BR /> | ||
| - | [[1tu7]], [[2hnl]] - OvGST + GSH - Onchocerca volvulus<br /> | + | [[1tu7]], [[2hnl]] - OvGST + GSH - ''Onchocerca volvulus''<br /> |
[[5gss]], [[6gss]], [[7gss]], [[8gss]], [[19gs]], [[3dd3]] - hGST + GSH<BR /> | [[5gss]], [[6gss]], [[7gss]], [[8gss]], [[19gs]], [[3dd3]] - hGST + GSH<BR /> | ||
[[1md3]], [[1md4]], [[1px6]], [[1px7]], [[1kbn]] - hGST (mutant) + GSH<BR /> | [[1md3]], [[1md4]], [[1px6]], [[1px7]], [[1kbn]] - hGST (mutant) + GSH<BR /> | ||
| - | [[3t2u]] - GST + GSH – Wuchereria bancrofti | + | [[3t2u]] - GST + GSH – ''Wuchereria bancrofti'' |
===GST π class complex=== | ===GST π class complex=== | ||
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===GST χ class=== | ===GST χ class=== | ||
| - | [[3ppu]] - GST + GSH – Phanerochaete chrysosporium | + | [[3ppu]] - GST + GSH – ''Phanerochaete chrysosporium'' |
===GST ω class=== | ===GST ω class=== | ||
Revision as of 11:04, 18 December 2012
Glutathione S-transferase (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal.
GST
4hz4 – GST – Actinobacillus pleuropneumoniae
1gsb, 1gsc – rGST – rat
3ubk – LiGST – Leptospira interrogans
3uap - GST – Methylococcus capsulatus
1aw9 - cGST III – corn
1okt – PfGST – Plasmodium falciparum
3fr6 - PfGST (mutant)
1tw9 – GST - Heligmosomoides polygyrus
1yq1 - CeGST – Caenorhabditis elegans
1y6e - SjGST – Schistosoma japonicum
2fno, 3lq7 - AtGST – Agrobacterium tumefaciens
2on7 – NaGST-1 – Necator americanus
3erf - yGST II – yeast
3f6f – DmGST – Drosophila melanogaster
3lxt - PsfGST – Pseudomonas fluorescens
4eci - PaGST – Pseudomonas aeruginosa
3niv - GST – Legionella pneumophila
3tot - RsGST – Ralstonia solanacearum
3ay8 - siGST – silkworm
GST binary complex with GSH
2x64 – GST + GSH – Xylella fastidiosa
4hz2 - GST + GSH - Xanthobacter autotrophicus
4ecj - PaGST + GSH
1fhe, 2fhe - GST + GSH – Fasciola hepatica
1pmt, 2pmt - GST + GSH – Proteus mirabilis
1m0u, 3gh6 - DmGST + GSH
1oe7, 1oe8 - ShGST + GSH – Schistosoma haematobium
1u3i - GST + GSH - Schistosoma mansoni
1oyj - GST + GSH - rice
1u87 - SjGST + GSH
2dsa, 2gdr - GST + GSH – Burkholderia xenovorans
2on5 – NaGST-2 + GSH
2nto - OaGST + GSH – Ochrobactrum anthropi
2pvq - OaGST (mutant) + GSH
3ibh - yGST II + GSH
3fr9 - PfGST + GSH
3m3m - PsfGST + GSH
3lsz - GST + GSH – Rhodobacter sphaeroides
3n5o - GST + GSH – Coccidioides immitis
3tou - RsGST + GSH
3uar - McGST + GSH
4g9h, 4gci - GST + GSH – Yersinia pestis
4gf0 - GST + GSH - Sulfitobacter
GST binary complex
3ubl - LiGST + GSH derivative
2gsq – GST + GSH derivative – squid
2gst, 3gst, 4gst, 5gst, 1gss - rGST + GSH derivative
1gnw - AtGST + GSH derivative – Arabidopsis thaliana
1aqv - hGST + GSH derivative – human
1gtb, 1gta - SjGST + praziquantel
1m99, 1m9a, 1m9b - SjGST + GSH derivative
1q4j, 2aaw, 3frc - PfGST + GSH derivative
3fr3 - PfGST (mutant) + GSH derivative
1bx9 - AtGST + herbicide
1bye - cGST I + herbicide
1axd – cGST I + lactoyl-GSH
1a0f, 1n2a - GST + GSH derivative – Eschericia coli
1f2e - GST + GSH derivative – Sphingomonas paucimobilis
1mtc - rGST + GSH derivative
1ua5 - SjGST + GSH derivative
1u88 - SjGST (mutant) + GSH derivative
3erg - yGST II + GSH derivative
3qmz - yGST + dynein heavy chain
2ycd - AtGST + GSH derivative
GST α class
1guh, 1gsd, 1k3o, 1pkz – hGST A1-1
1xwg, 3q74, 3u6v - hGST A1-1 (mutant)
1gum - hGST A4-4
1guk - mGST A4-4 – mouse
1vf4 - GgGST A1-1 - chicken
GST α class complex with GSH
1pkw - hGST + GSH
1usb - hGST (mutant) + GSH
1f3a - mGST A1-1+ GSH
3i69, 3i6a - hGST A1-1 (mutant)+ GSH
2wju - hGST A2-2 + GSH
4acs - hGST A2-2 (mutant) + GSH
1tdi - hGST A3-3 + GSH
1vf1 - GgGST A1-1 + GSH
GST α class complex
1gsf – hGST A1-1 + ethacrynic acid
1ags, 1pl2, 1ydk, 2r3x, 2r6k, 3ktl, 3l0h – hGST (mutant) + GSH derivative
1k3l, 1k3y, 1pl1 - hGST + GSH derivative
1gse – hGST (mutant) + GSH + ethacrynic acid
3ik9 - hGST A1-1 + GSDN
2vct - hGST A2-2 + steroid
2vcv - hGST A3-3 + steroid
1gul - hGST A4-4+ iodobenzyl-GSH
3ik7 - hGST A4-4 + GSDHN
1b48 - mGST A4-4 + GSH derivative
1f3b - mGST A1-1 + GSH derivative
1ml6 - mGST A2-2+ GSH derivative
1ev4, 1ev9 - rGST A1-1 (mutant) + GSH derivative
1vf2, 1vf3 – GgGST A1-1 + GSH derivative
GST δ class
1r5a, 1v2a, 1pn9 - GST + GSH derivative - Anopheles cracens
3ein - DmGST + GSH
3vk9 - siGST
GST ε class
2il3 - AgGST – Anopheles gambiae
2imi - AgGST + GSH
2imk - AgGST + GSH derivative
GST κ class
3rpp - hGST
1r4w - rGST + GSH derivative
1yzx, 3rpn - hGST + GSH derivative
GST μ class
1gsb, 1gsc – rGST
6gsu, 6gsv, 6gsw, 6gsx, 6gsy, 5fwg, 3fyg - rGST (mutant)
1gtu, 2gtu, 3gtu, 4gtu - hGST
2dc5 - mGST
2wrt - GST – Fasciola hepatica
GST μ class complex with GSH
1xw5, 1xw6 - hGST + GSH
2f8f - mGST (mutant) + GSH
3crt - SjGST + GSH
3cru, 3d0z - SjGST (mutant) + GSH
GST μ class complex
1gst - GgGST + GSH derivative
1c72 - GgGST + conjugate
1hna, 1hnb, 1hnc, 1xwk, 1ykc, 1yj6, 2ab6, 2f3m – hGST + GSH derivative
2c4j - hGST (mutant) + GSH derivative
1b4p - rGST + GSH derivative
3gur - hGST + GSH + drug
3gus - hGST + drug
GST ν class
2ws2 - GST – Haemonchus contortus
GST π class
1bay - mGST
10gs, 14gs, 16gs, 1lbk - hGST
22gs, 1eog, 1eoh, 3hjm, 3hkr, 3kmn - hGST (mutant)
GST π class complex with GSH
1gsy - mGST + GSH
1tu7, 2hnl - OvGST + GSH - Onchocerca volvulus
5gss, 6gss, 7gss, 8gss, 19gs, 3dd3 - hGST + GSH
1md3, 1md4, 1px6, 1px7, 1kbn - hGST (mutant) + GSH
3t2u - GST + GSH – Wuchereria bancrofti
GST π class complex
1gss – rGST + GSH derivative
1tu8 - OvGST + GSH derivative
1glq, 1glp, 2glr, 1gti - mGST + GSH derivative
2oac, 2oad, 2oa7, 3o76 - mGST (mutant) + GSH derivative
2gss, 3dgq – hGST + ethacrynic acid
3n9j - hGST + ethacrynic acid derivative
3gss, 11gs – hGST + ethacrynic acid + GSH
3hjo, 3km6, 3kmo - hGST (mutant) + ethacrynic acid + GSH
1pgt, 2pgt, 4gss, 17gs, 2j9h, 3csi - hGST (mutant) + GSH derivative
1aqw, 1aqx, 9gss, 12gs, 18gs, 3pgt, 4pgt, 1zgn, 2a2r, 2a2s, 3csh - hGST + GSH derivative
20gs - hGST + cibacron blue
13gs, 3csj - hGST + drug
3ie3 - hGST (mutant) + drug
GST ρ class
3qav - AcGST – Atlantic clam
3qaw - AcGST + GSH
GST σ class
2c8u, 2cai - ShGST (mutant)
2ca8 - ShGST + GSH
1zl9 - CeGST + GSH
4ec0, 4edz, 4ee0, 4edy, 1iyh, 1iyi, 2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 - hGST + GSH
3vi7 - hGST (mutant) + GSH
1v40, 2cvd, 3ee2, 3kxo - hGST + GSH + inhibitor
3vi5, 3vi7 - hGST (mutant) + GSH + inhibitor
2caq - ShGST (mutant) + GSH
1pd2 - rGST + GSH
2c80 - ShGST + GSH derivative
GST ϑ class
2ljr, 2c3n - hGST
2c3t - hGST (mutant)
1ljr - hGST + GSH
3mak - DmGST + GSH
3ljr - hGST + GSH derivative
2c3q - hGST (mutant) + GSH derivative
GST χ class
3ppu - GST + GSH – Phanerochaete chrysosporium
GST ω class
1eem – hGST
3q18, 3vln - hGST (mutant)
3rbt - siGST
3lfl - hGST + GSH
3qag, 3q19 - hGST (mutant) + GSH
GST ζ class
1e6b – AtGST
2cz3 - mGST
2cz2 - mGST + GSH
GST τ class
1gwc - GST – wheat
2vo4 - sGST + GSH derivative – soybean
3fhs - sGST + GSH
Microsomal GST
2h8a - rGST + GSH
