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3oyp

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[[Image:3oyp.png|left|200px]]
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==HCV NS3/4A in complex with ligand 3==
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<StructureSection load='3oyp' size='340' side='right' caption='[[3oyp]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oyp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_japanese) Hepatitis c virus (isolate japanese)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OYP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Y8:(4R)-4-[(7-BROMOISOQUINOLIN-1-YL)OXY]-L-PROLINE'>0Y8</scene>, <scene name='pdbligand=0Y9:(1R,2S)-1-AMINO-2-ETHENYLCYCLOPROPANECARBOXYLIC+ACID'>0Y9</scene>, <scene name='pdbligand=0YA:CYCLOPROPANESULFONAMIDE'>0YA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=PPI:PROPANOIC+ACID'>PPI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oyp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oyp RCSB], [http://www.ebi.ac.uk/pdbsum/3oyp PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Designing selective inhibitors of proteases has proven problematic, in part because pharmacophores that confer potency exploit the conserved catalytic apparatus. We developed a fundamentally different approach by designing irreversible inhibitors that target noncatalytic cysteines that are structurally unique to a target in a protein family. We have successfully applied this approach to the important therapeutic target HCV protease, which has broad implications for the design of other selective protease inhibitors.
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{{STRUCTURE_3oyp| PDB=3oyp | SCENE= }}
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Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.,Hagel M, Niu D, St Martin T, Sheets MP, Qiao L, Bernard H, Karp RM, Zhu Z, Labenski MT, Chaturvedi P, Nacht M, Westlin WF, Petter RC, Singh J Nat Chem Biol. 2011 Jan;7(1):22-4. Epub 2010 Nov 28. PMID:21113170<ref>PMID:21113170</ref>
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===HCV NS3/4A in complex with ligand 3===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21113170}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3oyp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_japanese) Hepatitis c virus (isolate japanese)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OYP OCA].
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</StructureSection>
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[[Category: Bernard, H]]
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==Reference==
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[[Category: Chaturvedi, P C]]
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<ref group="xtra">PMID:021113170</ref><references group="xtra"/>
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[[Category: Hagel, M]]
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[[Category: Bernard, H.]]
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[[Category: Karp, R M]]
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[[Category: Chaturvedi, P C.]]
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[[Category: Labenski, M T]]
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[[Category: Hagel, M.]]
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[[Category: Martin, T St]]
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[[Category: Karp, R M.]]
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[[Category: Nacht, M]]
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[[Category: Labenski, M T.]]
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[[Category: Niu, D]]
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[[Category: Martin, T St..]]
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[[Category: Petter, R C]]
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[[Category: Nacht, M.]]
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[[Category: Qiao, L]]
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[[Category: Niu, D.]]
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[[Category: Sheets, M P]]
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[[Category: Petter, R C.]]
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[[Category: Singh, J]]
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[[Category: Qiao, L.]]
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[[Category: Westlin, W F]]
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[[Category: Sheets, M P.]]
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[[Category: Zhu, Z]]
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[[Category: Singh, J.]]
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[[Category: Westlin, W F.]]
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[[Category: Zhu, Z.]]
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[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 12:14, 9 December 2014

HCV NS3/4A in complex with ligand 3

3oyp, resolution 2.76Å

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