3zfg

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m (Protected "3zfg" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_3zfg| PDB=3zfg | SCENE= }}
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===Human enterovirus 71 in complex with capsid binding inhibitor WIN51711===
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The entry 3zfg is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/A9X4C2_9ENTO A9X4C2_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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Authors: Plevka, P., Perera, R., Yap, M.L., Cardosa, J., Kuhn, R.J., Rossmann, M.G.
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==About this Structure==
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[[3zfg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_enterovirus_71 Human enterovirus 71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFG OCA].
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Description: Human enterovirus 71 in complex with capsid binding inhibitor WIN51711
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[[Category: Human enterovirus 71]]
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[[Category: Cardosa, J.]]
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[[Category: Kuhn, R J.]]
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[[Category: Perera, R.]]
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[[Category: Plevka, P.]]
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[[Category: Rossmann, M G.]]
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[[Category: Yap, M L.]]
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[[Category: Ev71]]
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[[Category: Inhibitor]]
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[[Category: Picornavirus]]
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[[Category: Virus]]

Revision as of 08:53, 27 March 2013

Template:STRUCTURE 3zfg

Human enterovirus 71 in complex with capsid binding inhibitor WIN51711

Function

[A9X4C2_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

3zfg is a 4 chain structure with sequence from Human enterovirus 71. Full crystallographic information is available from OCA.

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OCA

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