4hx5

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'''Unreleased structure'''
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{{STRUCTURE_4hx5| PDB=4hx5 | SCENE= }}
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===Crystal structure of 11 beta-HSD1 in complex with SAR184841===
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{{ABSTRACT_PUBMED_23478147}}
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The entry 4hx5 is ON HOLD until Nov 09 2014
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==Disease==
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[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
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Authors: Loenze, P., Schimanski-Breves, S., Engel, C.K.
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==Function==
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[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
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Description: Crystal structure of 11 beta-HSD1 in complex with SAR184841
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==About this Structure==
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[[4hx5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HX5 OCA].
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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[[Category: Homo sapiens]]
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[[Category: Engel, C K.]]
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[[Category: Loenze, P.]]
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[[Category: Schimanski-Breves, S.]]
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[[Category: 11beta]]
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[[Category: Dehydrogenase]]
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[[Category: Hydroxysteroid]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 07:42, 8 May 2013

Template:STRUCTURE 4hx5

Contents

Crystal structure of 11 beta-HSD1 in complex with SAR184841

Template:ABSTRACT PUBMED 23478147

Disease

[DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

Function

[DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

About this Structure

4hx5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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