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4i4h

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'''Unreleased structure'''
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{{STRUCTURE_4i4h| PDB=4i4h | SCENE= }}
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===Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir===
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The entry 4i4h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
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Authors: Sevrioukova, I.F., Poulos, T.L.
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==About this Structure==
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[[4i4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4H OCA].
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Description: Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Poulos, T L.]]
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[[Category: Sevrioukova, I F.]]
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[[Category: Cytochrome b5]]
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[[Category: Cytochrome p450]]
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[[Category: Cytochrome p450 reductase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 11:29, 24 April 2013

Template:STRUCTURE 4i4h

Contents

Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir

Function

[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]

About this Structure

4i4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Miyazawa M, Shindo M, Shimada T. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metab Dispos. 2001 Feb;29(2):200-5. PMID:11159812

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