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1so9
From Proteopedia
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| - | [[Image:1so9.gif|left|200px]] | + | [[Image:1so9.gif|left|200px]] |
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| - | '''Solution Structure of apoCox11, 30 structures''' | + | {{Structure |
| + | |PDB= 1so9 |SIZE=350|CAPTION= <scene name='initialview01'>1so9</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CTAG, R00908, SMC00012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382 Sinorhizobium meliloti]) | ||
| + | }} | ||
| + | |||
| + | '''Solution Structure of apoCox11, 30 structures''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SO9 is a [ | + | 1SO9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SO9 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:[http:// | + | Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15181013 15181013] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sinorhizobium meliloti]] | [[Category: Sinorhizobium meliloti]] | ||
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[[Category: immunoglobulin-like fold]] | [[Category: immunoglobulin-like fold]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:33 2008'' |
Revision as of 12:07, 20 March 2008
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| Gene: | CTAG, R00908, SMC00012 (Sinorhizobium meliloti) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of apoCox11, 30 structures
Overview
Cytochrome c oxidase assembly process involves many accessory proteins including Cox11, which is a copper-binding protein required for Cu incorporation into the Cu(B) site of cytochrome c oxidase. In a genome wide search, a number of Cox11 homologs are found in all of the eukaryotes with complete genomes and in several Gram-negative bacteria. All of them possess a highly homologous soluble domain and contain an N-terminal fragment that anchors the protein to the membrane. An anchor-free construct of 164 amino acids was obtained from Sinorhizobium meliloti, and the first structure of this class of proteins is reported here. The apoform has an immunoglobulin-like fold with a novel type of beta-strand organization. The copper binding motif composed of two highly conserved cysteines is located on one side of the beta-barrel structure. The apoprotein is monomeric in the presence of dithiothreitol, whereas it dimerizes in the absence of the reductant. When copper(I) binds, NMR and extended x-ray absorption fine structure (EXAFS) data indicate a dimeric protein state with two thiolates bridging two copper(I) ions. The present results advance the knowledge on the poorly understood molecular aspects of cytochrome c oxidase assembly.
About this Structure
1SO9 is a Single protein structure of sequence from Sinorhizobium meliloti. Full crystallographic information is available from OCA.
Reference
Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:15181013
Page seeded by OCA on Thu Mar 20 14:07:33 2008
Categories: Single protein | Sinorhizobium meliloti | Banci, L. | Bertini, I. | Cantini, F. | Ciofi-Baffoni, S. | Gonnelli, L. | Mangani, S. | SPINE, Structural Proteomics in Europe. | Copper protein | Cytochrome c oxidase assembly | Immunoglobulin-like fold | Spine | Structural genomic | Structural proteomics in europe
