1sox

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[[Image:1sox.gif|left|200px]]<br /><applet load="1sox" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1sox.gif|left|200px]]
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caption="1sox, resolution 1.9&Aring;" />
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'''SULFITE OXIDASE FROM CHICKEN LIVER'''<br />
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{{Structure
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|PDB= 1sox |SIZE=350|CAPTION= <scene name='initialview01'>1sox</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1]
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|GENE=
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}}
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'''SULFITE OXIDASE FROM CHICKEN LIVER'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SOX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MTE:'>MTE</scene>, <scene name='pdbligand=MO:'>MO</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=EPE:'>EPE</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOX OCA].
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1SOX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOX OCA].
==Reference==
==Reference==
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Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase., Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC, Cell. 1997 Dec 26;91(7):973-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9428520 9428520]
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Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase., Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC, Cell. 1997 Dec 26;91(7):973-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9428520 9428520]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: sulfite oxidation]]
[[Category: sulfite oxidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:03:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:47 2008''

Revision as of 12:07, 20 March 2008

Image:1sox.gif


PDB ID 1sox

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: , , , , and
Activity: Sulfite oxidase, with EC number 1.8.3.1
Coordinates: save as pdb, mmCIF, xml



SULFITE OXIDASE FROM CHICKEN LIVER


Overview

The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfite oxidase at 1.9 A resolution reveals that each monomer of the dimeric enzyme consists of three domains. At the active site, the Mo is penta-coordinated by three sulfur ligands, one oxo group, and one water/hydroxo. A sulfate molecule adjacent to the Mo identifies the substrate binding pocket. Four variants associated with sulfite oxidase deficiency have been identified: two mutations are near the sulfate binding site, while the other mutations occur within the domain mediating dimerization.

About this Structure

1SOX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase., Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC, Cell. 1997 Dec 26;91(7):973-83. PMID:9428520

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