This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4g6j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:4g6j.jpg|left|200px]]
 
- 
{{STRUCTURE_4g6j| PDB=4g6j | SCENE= }}
{{STRUCTURE_4g6j| PDB=4g6j | SCENE= }}
- 
===Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab===
===Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab===
- 
{{ABSTRACT_PUBMED_23041424}}
{{ABSTRACT_PUBMED_23041424}}
 +
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
==About this Structure==
==About this Structure==
[[4g6j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6J OCA].
[[4g6j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6J OCA].
 +
 +
==See Also==
 +
*[[Interleukin|Interleukin]]
 +
 +
==Reference==
 +
<ref group="xtra">PMID:023041424</ref><references group="xtra"/><references/>
[[Category: Blech, M.]]
[[Category: Blech, M.]]
[[Category: Hoerer, S.]]
[[Category: Hoerer, S.]]

Revision as of 04:33, 18 July 2013

Template:STRUCTURE 4g6j

Contents

Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab

Template:ABSTRACT PUBMED 23041424

Function

[IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]

About this Structure

4g6j is a 3 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Blech M, Peter D, Fischer P, Bauer MM, Hafner M, Zeeb M, Nar H. One Target-Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1beta J Mol Biol. 2012 Oct 3. pii: S0022-2836(12)00786-3. doi:, 10.1016/j.jmb.2012.09.021. PMID:23041424 doi:10.1016/j.jmb.2012.09.021
  1. ↑ Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J. Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. PMID:3920526

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g6j"
Personal tools