4g6j

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[[Image:4g6j.jpg|left|200px]]
 
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{{STRUCTURE_4g6j| PDB=4g6j | SCENE= }}
{{STRUCTURE_4g6j| PDB=4g6j | SCENE= }}
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===Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab===
===Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab===
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{{ABSTRACT_PUBMED_23041424}}
{{ABSTRACT_PUBMED_23041424}}
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==Function==
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[[http://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
==About this Structure==
==About this Structure==
[[4g6j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6J OCA].
[[4g6j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6J OCA].
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==See Also==
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*[[Interleukin|Interleukin]]
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==Reference==
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<ref group="xtra">PMID:023041424</ref><references group="xtra"/><references/>
[[Category: Blech, M.]]
[[Category: Blech, M.]]
[[Category: Hoerer, S.]]
[[Category: Hoerer, S.]]

Revision as of 04:33, 18 July 2013

Template:STRUCTURE 4g6j

Contents

Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab

Template:ABSTRACT PUBMED 23041424

Function

[IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.[1]

About this Structure

4g6j is a 3 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Blech M, Peter D, Fischer P, Bauer MM, Hafner M, Zeeb M, Nar H. One Target-Two Different Binding Modes: Structural Insights into Gevokizumab and Canakinumab Interactions to Interleukin-1beta J Mol Biol. 2012 Oct 3. pii: S0022-2836(12)00786-3. doi:, 10.1016/j.jmb.2012.09.021. PMID:23041424 doi:10.1016/j.jmb.2012.09.021
  1. ↑ Van Damme J, De Ley M, Opdenakker G, Billiau A, De Somer P, Van Beeumen J. Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature. 1985 Mar 21-27;314(6008):266-8. PMID:3920526

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