1pjw
From Proteopedia
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| - | [[ | + | ==Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein== |
| + | <StructureSection load='1pjw' size='340' side='right' caption='[[1pjw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1pjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Japanese_encephalitis_virus Japanese encephalitis virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJW FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjw RCSB], [http://www.ebi.ac.uk/pdbsum/1pjw PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The flavivirus envelope protein is the dominant antigen in eliciting neutralizing antibodies and plays an important role in inducing immunologic responses in the infected host. We have determined the solution structure of the major antigenic domain (domain III) of the Japanese encephalitis virus (JEV) envelope protein. The JEV domain III forms a beta-barrel type structure composed of six antiparallel beta-strands resembling the immunoglobulin constant domain. We have also identified epitopes of the JEV domain III to its neutralizing antibody by chemical shift perturbation measurements. Site-directed mutagenesis experiments are performed to confirm the NMR results. Our study provides a structural basis for understanding the mechanism of immunologic protection and for rational design of vaccines effective against flaviviruses. | ||
| - | + | Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein.,Wu KP, Wu CW, Tsao YP, Kuo TW, Lou YC, Lin CW, Wu SC, Cheng JW J Biol Chem. 2003 Nov 14;278(46):46007-13. Epub 2003 Sep 2. PMID:12952958<ref>PMID:12952958</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Japanese encephalitis virus]] | [[Category: Japanese encephalitis virus]] | ||
[[Category: Lin, C W.]] | [[Category: Lin, C W.]] | ||
Revision as of 21:08, 28 September 2014
Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein
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