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1srs

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[[Image:1srs.gif|left|200px]]<br /><applet load="1srs" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1srs.gif|left|200px]]
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caption="1srs, resolution 3.200&Aring;" />
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'''SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA'''<br />
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{{Structure
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|PDB= 1srs |SIZE=350|CAPTION= <scene name='initialview01'>1srs</scene>, resolution 3.200&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= SRF CORE (RESIDUES 132-223) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1SRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRS OCA].
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1SRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRS OCA].
==Reference==
==Reference==
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Structure of serum response factor core bound to DNA., Pellegrini L, Tan S, Richmond TJ, Nature. 1995 Aug 10;376(6540):490-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7637780 7637780]
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Structure of serum response factor core bound to DNA., Pellegrini L, Tan S, Richmond TJ, Nature. 1995 Aug 10;376(6540):490-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7637780 7637780]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transcription regulation]]
[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:08:51 2008''

Revision as of 12:08, 20 March 2008

Image:1srs.gif


PDB ID 1srs

Drag the structure with the mouse to rotate
, resolution 3.200Å
Gene: SRF CORE (RESIDUES 132-223) (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA


Contents

Overview

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

Disease

Known disease associated with this structure: Osteoarthritis of hip, female-specific, susceptibility to OMIM:[605083]

About this Structure

1SRS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of serum response factor core bound to DNA., Pellegrini L, Tan S, Richmond TJ, Nature. 1995 Aug 10;376(6540):490-8. PMID:7637780

Page seeded by OCA on Thu Mar 20 14:08:51 2008

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