1st4

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[[Image:1st4.jpg|left|200px]]<br /><applet load="1st4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1st4.jpg|left|200px]]
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caption="1st4, resolution 2.02&Aring;" />
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'''Structure of DcpS bound to m7GpppA'''<br />
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{{Structure
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|PDB= 1st4 |SIZE=350|CAPTION= <scene name='initialview01'>1st4</scene>, resolution 2.02&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene> and <scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE'>GTA</scene>
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|ACTIVITY=
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|GENE= DCPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Structure of DcpS bound to m7GpppA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ST4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=YT3:'>YT3</scene> and <scene name='pdbligand=GTA:'>GTA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ST4 OCA].
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1ST4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ST4 OCA].
==Reference==
==Reference==
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Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15068804 15068804]
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Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15068804 15068804]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rna decay]]
[[Category: rna decay]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:09:24 2008''

Revision as of 12:09, 20 March 2008

Image:1st4.jpg


PDB ID 1st4

Drag the structure with the mouse to rotate
, resolution 2.02Å
Ligands: and
Gene: DCPS (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structure of DcpS bound to m7GpppA


Overview

Complete removal of residual N-7 guanine cap from degraded messenger RNA is necessary to prevent accumulation of intermediates that might interfere with RNA processing, export, and translation. The human scavenger decapping enzyme, DcpS, catalyzes residual cap hydrolysis following mRNA degradation, releasing N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. DcpS structures bound to m(7)GpppG or m(7)GpppA reveal an asymmetric DcpS dimer that simultaneously creates an open nonproductive DcpS-cap complex and a closed productive DcpS-cap complex that alternate via 30 A domain movements. Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis.

About this Structure

1ST4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:15068804

Page seeded by OCA on Thu Mar 20 14:09:24 2008

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