1p9l

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[[Image:1p9l.png|left|200px]]
 
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{{STRUCTURE_1p9l| PDB=1p9l | SCENE= }}
{{STRUCTURE_1p9l| PDB=1p9l | SCENE= }}
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===Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC===
===Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC===
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{{ABSTRACT_PUBMED_12962488}}
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{{ABSTRACT_PUBMED_12962488}}
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==Function==
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[[http://www.uniprot.org/uniprot/DAPB_MYCTU DAPB_MYCTU]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.<ref>PMID:12962488</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012962488</ref><references group="xtra"/>
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<ref group="xtra">PMID:012962488</ref><references group="xtra"/><references/>
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[[Category: Dihydrodipicolinate reductase]]
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[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Blanchard, J S.]]
[[Category: Blanchard, J S.]]

Revision as of 05:32, 6 November 2013

Template:STRUCTURE 1p9l

Contents

Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC

Template:ABSTRACT PUBMED 12962488

Function

[DAPB_MYCTU] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.[1]

About this Structure

1p9l is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:http://dx.doi.org/10.1021/bi030044v
  1. ↑ Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:http://dx.doi.org/10.1021/bi030044v

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