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1pwa

From Proteopedia

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[[Image:1pwa.png|left|200px]]
 
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{{STRUCTURE_1pwa| PDB=1pwa | SCENE= }}
{{STRUCTURE_1pwa| PDB=1pwa | SCENE= }}
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===Crystal structure of Fibroblast Growth Factor 19===
===Crystal structure of Fibroblast Growth Factor 19===
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{{ABSTRACT_PUBMED_14730967}}
{{ABSTRACT_PUBMED_14730967}}
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==Function==
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[[http://www.uniprot.org/uniprot/FGF19_HUMAN FGF19_HUMAN]] Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.<ref>PMID:12815072</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:19085950</ref>
==About this Structure==
==About this Structure==
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[[1pwa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWA OCA].
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[[1pwa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWA OCA].
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==See Also==
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*[[Fibroblast growth factor|Fibroblast growth factor]]
==Reference==
==Reference==
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<ref group="xtra">PMID:014730967</ref><references group="xtra"/>
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<ref group="xtra">PMID:014730967</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Blundell, T L.]]
[[Category: Blundell, T L.]]
[[Category: Chirgadze, D.]]
[[Category: Chirgadze, D.]]

Revision as of 08:17, 16 April 2014

Template:STRUCTURE 1pwa

Contents

Crystal structure of Fibroblast Growth Factor 19

Template:ABSTRACT PUBMED 14730967

Function

[FGF19_HUMAN] Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.[1] [2] [3] [4]

About this Structure

1pwa is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry. 2004 Jan 27;43(3):629-40. PMID:14730967 doi:10.1021/bi035320k
  1. ↑ Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, Kozarsky KF, Donahee M, Wang DY, Mansfield TA, Kliewer SA, Goodwin B, Jones SA. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 2003 Jul 1;17(13):1581-91. Epub 2003 Jun 18. PMID:12815072 doi:10.1101/gad.1083503
  2. ↑ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700. Epub 2006 Apr 4. PMID:16597617 doi:10.1074/jbc.M601252200
  3. ↑ Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007 Sep 14;282(37):26687-95. Epub 2007 Jul 10. PMID:17623664 doi:10.1074/jbc.M704165200
  4. ↑ Song KH, Li T, Owsley E, Strom S, Chiang JY. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology. 2009 Jan;49(1):297-305. doi: 10.1002/hep.22627. PMID:19085950 doi:http://dx.doi.org/10.1002/hep.22627

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