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1svb
From Proteopedia
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| - | [[Image:1svb.gif|left|200px]] | + | [[Image:1svb.gif|left|200px]] |
| - | + | ||
| - | '''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS''' | + | {{Structure |
| + | |PDB= 1svb |SIZE=350|CAPTION= <scene name='initialview01'>1svb</scene>, resolution 1.9Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SVB is a [ | + | 1SVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVB OCA]. |
==Reference== | ==Reference== | ||
| - | The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:[http:// | + | The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7753193 7753193] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tick-borne encephalitis virus]] | [[Category: Tick-borne encephalitis virus]] | ||
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[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:10:04 2008'' |
Revision as of 12:10, 20 March 2008
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| , resolution 1.9Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS
Overview
The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.
About this Structure
1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.
Reference
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193
Page seeded by OCA on Thu Mar 20 14:10:04 2008
