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1sxr
From Proteopedia
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| - | [[Image:1sxr.gif|left|200px]] | + | [[Image:1sxr.gif|left|200px]] |
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| - | '''Drosophila Peptidoglycan Recognition Protein (PGRP)-SA''' | + | {{Structure |
| + | |PDB= 1sxr |SIZE=350|CAPTION= <scene name='initialview01'>1sxr</scene>, resolution 1.56Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Drosophila Peptidoglycan Recognition Protein (PGRP)-SA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1SXR is a [ | + | 1SXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXR OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:[http:// | + | Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15223330 15223330] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: toll pathway]] | [[Category: toll pathway]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:11:01 2008'' |
Revision as of 12:11, 20 March 2008
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| , resolution 1.56Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Drosophila Peptidoglycan Recognition Protein (PGRP)-SA
Overview
Peptidoglycan recognition proteins (PGRPs) form a recently discovered protein family, which is conserved from insect to mammals and is implicated in the innate immune system by interacting with/or degrading microbial peptidoglycans (PGNs). Drosophila PGRP-SA is a member of this family of pattern recognition receptors and is involved in insect Toll activation. We report here the crystal structure of PGRP-SA at 1.56 A resolution, which represents the first example of a "recognition" PGRP. Comparison with the catalytic Drosophila PGRP-LB reveals an overall structure conservation with an L-shaped hydrophilic groove that is likely the PGN carbohydrate core binding site, but further suggests some possible functional homology between recognition and catalytic PGRPs. Consistent with sequence analysis, PGRP-SA does not contain the canonical zinc-binding residues found in catalytic PGRPs. However, substitution of the zinc-binding cysteine residue by serine, along with an altered coordinating histidine residue, assembles a constellation of residues that resembles a modified catalytic triad. The serine/histidine juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the catalytic water molecule found in PGRP-LB, tantalizingly suggests some hydrolytic function for this member of receptor PGRPs.
About this Structure
1SXR is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution., Reiser JB, Teyton L, Wilson IA, J Mol Biol. 2004 Jul 16;340(4):909-17. PMID:15223330
Page seeded by OCA on Thu Mar 20 14:11:01 2008
