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	http://cro.sagepub.com/content/10/3/337.full.pdf		http://cro.sagepub.com/content/10/3/337.full.pdf
-		+	Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000 Oct 27;103(3):467-79. PMID : [http://www.ncbi.nlm.nih.gov/pubmed/11081633 11081633]
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	== '''Proteopedia Page Contributors and Editors''' ==		== '''Proteopedia Page Contributors and Editors''' ==
	Delphine Trelat, Cécile Ehrhardt		Delphine Trelat, Cécile Ehrhardt

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Revision as of 22:36, 2 January 2013

Template:Sandbox ESBS 2012

spinqualitylabelsall models Crystal structure of P-selectin lectin/EGF domains complexed with SLeX Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of P-selectin lectin/EGF domains complexed with SLeX

Contents 1 Introduction 2 3D structure 3 Different role of the P-selectin 3.1 Role in leukocyte extravasation 3.2 Role in platelets recruitment 3.3 Role in cancer 4 References 5 Proteopedia Page Contributors and Editors

Introduction

Selectins are proteins that are include in a family of cell adhesion receptor involved in the leukocyte extravasation. There are 3 kinds of selectins :

E selectin localized in endothelial cells, L selectin found in leukocytes, and P selectins in platelets and endothelial cells.

In this page we will be focused only on P-Selectin.

3D structure

P-Selectin is a protein composed by 162 amino-acids residues in 4 different chains A, B, C and D. There are many domains in this protein : the EGF domain, the lectin domain and others called Sushi 1 to Sushi 9. There are the extracellular part of the protein. Finally, we find a transmembrane helix and a cytoplasmic domain.

EGF domain (Epidermal Growth Factor) coutains 30 to 40 amino-acids residues

Lectin domains (also known as C-type lectin domains) are classified in 17 groups (from I to XVII). P-Selectin lectin bellow to the group IV.

Different role of the P-selectin

Role in leukocyte extravasation

Leukocyte extravasation is the movement of leukocytes out of the circulatory system. First, the leukocytes is attracted by cytokines, secreted near the site of infection. Then, this leukocytes slow down and beggin rolling allong the surface of the vessel. He binds then tightly the vessel and immobilizates himself. Finally, he pass through gaps between epithelial cells. By this mecanism, the leukocyte arrives on the site of infection to neutralize the infection agent.

Role in platelets recruitment

Role in cancer

References

http://cro.sagepub.com/content/10/3/337.full.pdf

Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000 Oct 27;103(3):467-79. PMID : 11081633

Proteopedia Page Contributors and Editors

Delphine Trelat, Cécile Ehrhardt