This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Glycogen synthase kinase 3
From Proteopedia
(New page: {{STRUCTURE_4dit| PDB=4dit | SIZE=400| SCENE= |right|CAPTION=Human glycogen synthase 3 β complex with inhibitor, 4dit }} '''Glycogen synthase kinase 3''' (GSK-3) is a serine/threon...) |
|||
| Line 15: | Line 15: | ||
[[3m1s]], [[3pup]] - hGSK-3 β + Ru complex<br /> | [[3m1s]], [[3pup]] - hGSK-3 β + Ru complex<br /> | ||
[[3zdi]] - hGSK-3 β + Axin peptide + inhibitor | [[3zdi]] - hGSK-3 β + Axin peptide + inhibitor | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Revision as of 11:29, 2 January 2013
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase. GSK-3 is active in a number of intracellular signaling pathways. GSK-3 regulates glycogen synthase as well as other proteins. GSK-3 inhibition is studied as a therapeutic target in diseases like Alzheimer, diabetes, bipolar disorder and some cancers.
3D structures of glycogen synthase kinase 3
1i09, 1h8f – hGSK-3 β – human
1gng - hGSK-3 β + Frattide peptide
1o9u - hGSK-3 β + Axin peptide
1q4l, 1uv5, 1q5k, 1r0e, 2o5k, 2ow3, 3du8, 3f7z, 3f88, 3i4b, 3gb2, 3l1s, 3q3b, 3zrk, 3zrl, 3zrm, 3sd0, 4dit, 4afj, 4acc, 4acd, 4acg, 4ach, 3say - hGSK-3 β + inhibitor
1pyx, 1j1b - hGSK-3 β + AMPPNP
1j1c - hGSK-3 β + ADP
1q3d, 1q3w, 1q41 - hGSK-3 β + ATP-mimetic inhibitor
2jld - hGSK-3 β + Ru complex + peptide
3m1s, 3pup - hGSK-3 β + Ru complex
3zdi - hGSK-3 β + Axin peptide + inhibitor
