1t27
From Proteopedia
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| - | [[Image:1t27.jpg|left|200px]] | + | [[Image:1t27.jpg|left|200px]] |
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| - | '''THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE''' | + | {{Structure |
| + | |PDB= 1t27 |SIZE=350|CAPTION= <scene name='initialview01'>1t27</scene>, resolution 2.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= PITPN, PITPNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1T27 is a [ | + | 1T27 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry 1FVZ. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T27 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:[http:// | + | Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11104777 11104777] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lipid binding protein]] | [[Category: lipid binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:45 2008'' |
Revision as of 12:12, 20 March 2008
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| , resolution 2.20Å | |||||||
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| Ligands: | |||||||
| Gene: | PITPN, PITPNA (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE
Overview
Eukaryotic phosphatidylinositol transfer protein is a ubiquitous multifunctional protein that transports phospholipids between membrane surfaces and participates in cellular phospholipid metabolism during signal transduction and vesicular trafficking. The three-dimensional structure of the alpha-isoform of rat phosphatidylinositol transfer protein complexed with one molecule of phosphatidylcholine, one of its physiological ligands, has been determined to 2.2 A resolution by x-ray diffraction techniques. A single beta-sheet and several long alpha-helices define an enclosed internal cavity in which a single molecule of the phospholipid is accommodated with its polar head group in the center of the protein and fatty acyl chains projected toward the surface. Other structural features suggest mechanisms by which cytosolic phosphatidylinositol transfer protein interacts with membranes for lipid exchange and associates with a variety of lipid and protein kinases.
About this Structure
1T27 is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1FVZ. Full crystallographic information is available from OCA.
Reference
Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:11104777
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