1t2r
From Proteopedia
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| - | [[Image:1t2r.gif|left|200px]] | + | [[Image:1t2r.gif|left|200px]] |
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| - | '''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain''' | + | {{Structure |
| + | |PDB= 1t2r |SIZE=350|CAPTION= <scene name='initialview01'>1t2r</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1T2R is a [ | + | 1T2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA]. |
==Reference== | ==Reference== | ||
| - | Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:[http:// | + | Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15156196 15156196] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:12:57 2008'' |
Revision as of 12:13, 20 March 2008
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Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain
Overview
We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
About this Structure
1T2R is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nat Struct Mol Biol. 2004 Jun;11(6):576-7. Epub 2004 May 23. PMID:15156196
Page seeded by OCA on Thu Mar 20 14:12:57 2008
