4gbf
From Proteopedia
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| - | [[ | + | ==Crystal structure of the C-terminal domain of gp131 from bacteriophage phiKZ== |
| + | <StructureSection load='4gbf' size='340' side='right' caption='[[4gbf]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gbf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phikz Pseudomonas phage phikz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GBF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GBF FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169683 Pseudomonas phage phiKZ])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gbf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gbf RCSB], [http://www.ebi.ac.uk/pdbsum/4gbf PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Pseudomonas phage varphiKZ and its two close relatives varphiPA3 and 201varphi2-1 are very large bacteriophages that form a separate branch in phage classification because their genomes are very different from the rest of GenBank sequence data. The contractile tail of varphiKZ is built from at least 32 different proteins, but a definitive structural function is assigned to only one of them-the tail sheath protein. Here, we report the crystal structure of the C-terminal domain of another phiKZ tail protein, gene product 131 (gp131C). We show that gp131 is located at the periphery of the baseplate and possibly associates with fibers that emanate from the baseplate. Gp131C is a seven-bladed beta-propeller that has a shape of a skewed toroid. A small but highly conserved and negatively charged patch on the surface of gp131C might be important for substrate binding or for interaction with a different tail protein. | ||
| - | + | Crystal structure and location of gp131 in the bacteriophage phiKZ virion.,Sycheva LV, Shneider MM, Sykilinda NN, Ivanova MA, Miroshnikov KA, Leiman PG Virology. 2012 Sep 29. pii: S0042-6822(12)00442-4. doi:, 10.1016/j.virol.2012.09.001. PMID:23031178<ref>PMID:23031178</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Pseudomonas phage phikz]] | [[Category: Pseudomonas phage phikz]] | ||
| - | [[Category: Leiman, P G | + | [[Category: Leiman, P G]] |
| - | [[Category: Shneider, M M | + | [[Category: Shneider, M M]] |
| - | [[Category: Sycheva, L V | + | [[Category: Sycheva, L V]] |
[[Category: 7-bladed beta-propeller]] | [[Category: 7-bladed beta-propeller]] | ||
[[Category: At the periphery of the baseplate or in the fiber of bacteriophage phikz]] | [[Category: At the periphery of the baseplate or in the fiber of bacteriophage phikz]] | ||
[[Category: Possibly participates in binding of the phage to the host cell]] | [[Category: Possibly participates in binding of the phage to the host cell]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 10:23, 20 January 2015
Crystal structure of the C-terminal domain of gp131 from bacteriophage phiKZ
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