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2lze

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[[Image:2lze.png|left|200px]]
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==Ligase 10C==
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<StructureSection load='2lze' size='340' side='right' caption='[[2lze]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lze]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LZE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lze OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lze RCSB], [http://www.ebi.ac.uk/pdbsum/2lze PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a noncatalytic protein scaffold, we recently generated a new RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopted an entirely new structure with substantially enhanced conformational dynamics, demonstrating that a primordial fold with suitable flexibility is sufficient to carry out enzymatic function.
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{{STRUCTURE_2lze| PDB=2lze | SCENE= }}
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Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.,Chao FA, Morelli A, Iii JC, Churchfield L, Hagmann LN, Shi L, Masterson LR, Sarangi R, Veglia G, Seelig B Nat Chem Biol. 2012 Dec 9. doi: 10.1038/nchembio.1138. PMID:23222886<ref>PMID:23222886</ref>
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===Ligase 10C===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23222886}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lze]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZE OCA].
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</StructureSection>
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Chao, F.]]
[[Category: Chao, F.]]

Revision as of 11:33, 20 October 2014

Ligase 10C

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