4hpm

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'''Unreleased structure'''
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{{STRUCTURE_4hpm| PDB=4hpm | SCENE= }}
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===PCGF1 Ub fold (RAWUL)/BCORL1 PUFD Complex===
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{{ABSTRACT_PUBMED_23523425}}
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The entry 4hpm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/BCORL_HUMAN BCORL_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.<ref>PMID:17379597</ref> [[http://www.uniprot.org/uniprot/PCGF1_HUMAN PCGF1_HUMAN]] Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:15620699</ref> <ref>PMID:16943429</ref> <ref>PMID:17088287</ref>
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Authors: Junco, S.E., Wang, R., Gaipa, J., Taylor, A.B., Gearhart, M.D., Bardwell, V.J., Hart, P.J., Kim, C.A.
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==About this Structure==
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[[4hpm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPM OCA].
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Description: PCGF1 Ub fold (RAWUL)/BCORL1 PUFD Complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Bardwell, V J.]]
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[[Category: Gaipa, J.]]
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[[Category: Gearhart, M D.]]
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[[Category: Hart, P J.]]
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[[Category: Junco, S E.]]
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[[Category: Kim, C A.]]
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[[Category: Taylor, A B.]]
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[[Category: Wang, R.]]
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[[Category: Bcorl1]]
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[[Category: Chromatin regulator]]
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[[Category: Chromosomal protein]]
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[[Category: E3-ligase]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Nspc1]]
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[[Category: Nucleus]]
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[[Category: Pcgf1]]
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[[Category: Polycomb]]
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[[Category: Rawul]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription repressor]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc-finger]]

Revision as of 07:39, 2 May 2013

Template:STRUCTURE 4hpm

Contents

PCGF1 Ub fold (RAWUL)/BCORL1 PUFD Complex

Template:ABSTRACT PUBMED 23523425

Function

[BCORL_HUMAN] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.[1] [PCGF1_HUMAN] Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.[2] [3] [4]

About this Structure

4hpm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, Richard DJ, Forrest A, Spurdle A, Verdin E, Crossley M, Fanciulli M, Chenevix-Trench G, Young DB, Khanna KK. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem. 2007 May 18;282(20):15248-57. Epub 2007 Mar 22. PMID:17379597 doi:10.1074/jbc.M700246200
  2. ↑ Gong Y, Wang X, Liu J, Shi L, Yin B, Peng X, Qiang B, Yuan J. NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183. FEBS Lett. 2005 Jan 3;579(1):115-21. PMID:15620699 doi:10.1016/j.febslet.2004.11.056
  3. ↑ Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol. 2006 Sep;26(18):6880-9. PMID:16943429 doi:26/18/6880
  4. ↑ Gong Y, Yue J, Wu X, Wang X, Wen J, Lu L, Peng X, Qiang B, Yuan J. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element. Nucleic Acids Res. 2006;34(21):6158-69. Epub 2006 Nov 6. PMID:17088287 doi:gkl834

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