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1q1v
From Proteopedia
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| - | [[Image:1q1v.png|left|200px]] | ||
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{{STRUCTURE_1q1v| PDB=1q1v | SCENE= }} | {{STRUCTURE_1q1v| PDB=1q1v | SCENE= }} | ||
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===Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif=== | ===Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif=== | ||
| + | {{ABSTRACT_PUBMED_15238633}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN]] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene. | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/DEK_HUMAN DEK_HUMAN]] Involved in chromatin organization.<ref>PMID:17524367</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015238633</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015238633</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Devany, M.]] | [[Category: Devany, M.]] | ||
Revision as of 10:25, 24 March 2013
Contents |
Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif
Template:ABSTRACT PUBMED 15238633
Disease
[DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.
Function
[DEK_HUMAN] Involved in chromatin organization.[1]
About this Structure
1q1v is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Devany M, Kotharu NP, Matsuo H. Solution NMR structure of the C-terminal domain of the human protein DEK. Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633 doi:10.1110/ps.04797104
- ↑ Hu HG, Scholten I, Gruss C, Knippers R. The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1008-14. Epub 2007 May 21. PMID:17524367 doi:10.1016/j.bbrc.2007.05.019
