1tf0
From Proteopedia
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| - | [[Image:1tf0.gif|left|200px]] | + | [[Image:1tf0.gif|left|200px]] |
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| - | '''Crystal structure of the GA module complexed with human serum albumin''' | + | {{Structure |
| + | |PDB= 1tf0 |SIZE=350|CAPTION= <scene name='initialview01'>1tf0</scene>, resolution 2.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= PAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1260 Finegoldia magna]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the GA module complexed with human serum albumin''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TF0 is a [ | + | 1TF0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF0 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin., Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S, J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21. PMID:[http:// | + | Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin., Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S, J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15269208 15269208] |
[[Category: Finegoldia magna]] | [[Category: Finegoldia magna]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:29 2008'' |
Revision as of 12:17, 20 March 2008
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| , resolution 2.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | PAB (Finegoldia magna) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the GA module complexed with human serum albumin
Contents |
Overview
Many bactericide species express surface proteins that interact with human serum albumin (HSA). Protein PAB from the anaerobic bacterium Finegoldia magna (formerly Peptostreptococcus magnus) represents one of these proteins. Protein PAB contains a domain of 53 amino acid residues known as the GA module. GA homologs are also found in protein G of group C and G streptococci. Here we report the crystal structure of HSA in complex with the GA module of protein PAB. The model of the complex was refined to a resolution of 2.7 A and reveals a novel binding epitope located in domain II of the albumin molecule. The GA module is composed of a left-handed three-helix bundle, and residues from the second helix and the loops surrounding it were found to be involved in HSA binding. Furthermore, the presence of HSA-bound fatty acids seems to influence HSA-GA complex formation. F. magna has a much more restricted host specificity compared with C and G streptococci, which is also reflected in the binding of different animal albumins by proteins PAB and G. The structure of the HSA-GA complex offers a molecular explanation to this unusually clear example of bacterial adaptation.
Disease
Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]
About this Structure
1TF0 is a Protein complex structure of sequences from Finegoldia magna and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin., Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S, J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21. PMID:15269208
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