Sandbox Reserved 709
From Proteopedia
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===IMPORTIN ALPHA STRUCTURE=== | ===IMPORTIN ALPHA STRUCTURE=== | ||
Importin α is a soluble adaptor protein also known as karyopherin α. It has as a function to connect importin β and a protein which have a cNLS (classical Nuclear Localization Signal) in order to import this protein in the nucleus. | Importin α is a soluble adaptor protein also known as karyopherin α. It has as a function to connect importin β and a protein which have a cNLS (classical Nuclear Localization Signal) in order to import this protein in the nucleus. | ||
| + | A NLS is a basic residue-rich sequence with the following consensus sequence : | ||
| + | * Two adjacent basic amino acids (Arg or Lys). | ||
| + | * A spacer region of any 10 residues. | ||
| + | * At least three basic residues (Arg or Lys) in the five positions after the spacer region. | ||
| + | |||
| + | |||
==Reference== | ==Reference== | ||
Revision as of 20:05, 2 January 2013
Contents |
NUP50:IMPORTIN-ALPHA COMPLEX
Template:ABSTRACT PUBMED 16222336
About this Structure
2c1m is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
IMPORTIN ALPHA STRUCTURE
Importin α is a soluble adaptor protein also known as karyopherin α. It has as a function to connect importin β and a protein which have a cNLS (classical Nuclear Localization Signal) in order to import this protein in the nucleus. A NLS is a basic residue-rich sequence with the following consensus sequence :
- Two adjacent basic amino acids (Arg or Lys).
- A spacer region of any 10 residues.
- At least three basic residues (Arg or Lys) in the five positions after the spacer region.
Reference
- Matsuura Y, Stewart M. Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling. EMBO J. 2005 Nov 2;24(21):3681-9. Epub 2005 Oct 13. PMID:16222336
