1tgx
From Proteopedia
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| - | [[Image:1tgx.jpg|left|200px]] | + | [[Image:1tgx.jpg|left|200px]] |
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| - | '''X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES''' | + | {{Structure |
| + | |PDB= 1tgx |SIZE=350|CAPTION= <scene name='initialview01'>1tgx</scene>, resolution 1.55Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TGX is a [ | + | 1TGX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGX OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structure at 1.55 A of toxin gamma, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes., Bilwes A, Rees B, Moras D, Menez R, Menez A, J Mol Biol. 1994 May 27;239(1):122-36. PMID:[http:// | + | X-ray structure at 1.55 A of toxin gamma, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes., Bilwes A, Rees B, Moras D, Menez R, Menez A, J Mol Biol. 1994 May 27;239(1):122-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8196041 8196041] |
[[Category: Naja nigricollis]] | [[Category: Naja nigricollis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cytotoxin]] | [[Category: cytotoxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:13 2008'' |
Revision as of 12:18, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES
Overview
The crystal structure of toxin gamma from Naja nigricollis has been solved and refined to 1.55 A resolution. The final R-factor, computed with all X-ray data available, is 17.9%. The three-dimensional structure is characterized by a core formed by two beta-sheets organized in three extended loops. It is similar to that of cardiotoxin V4II from Naja mossambica mossambica, with the exception of the hydrophobic loop I. The flexibility and variability of the loops contrast sharply with the rigidity of the molecular core and its high degree of structural conservation among the cardiotoxin family. The most flexible loop II adopts different conformations in the three monomers forming the crystal asymmetric unit. These monomers form a trimer around an approximate 3-fold axis, with conserved hydrophobic side-chains on the outside and hydrophilic residues in the central channel or involved in interactions with the other molecules. The trimer thus resembles a membrane protein with a central channel that could allow the passage of small ions. It is proposed as a model for the insertion of cardiotoxin into a membrane.
About this Structure
1TGX is a Single protein structure of sequence from Naja nigricollis. Full crystallographic information is available from OCA.
Reference
X-ray structure at 1.55 A of toxin gamma, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes., Bilwes A, Rees B, Moras D, Menez R, Menez A, J Mol Biol. 1994 May 27;239(1):122-36. PMID:8196041
Page seeded by OCA on Thu Mar 20 14:18:13 2008
Categories: Naja nigricollis | Single protein | Bilwes, A. | Moras, D. | Rees, B. | CL | Cytotoxin
