1rju

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[[Image:1rju.png|left|200px]]
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==Crystal structure of a truncated form of yeast copper thionein==
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<StructureSection load='1rju' size='340' side='right' caption='[[1rju]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RJU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fmy|1fmy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rju OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rju RCSB], [http://www.ebi.ac.uk/pdbsum/1rju PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report here the crystal structure of yeast copper thionein (Cu-MT), determined at 1.44-A resolution. The Cu-MT structure shows the largest known oligonuclear Cu(I) thiolate cluster in biology, consisting of six trigonally and two digonally coordinated Cu(I) ions. This is at variance with the results from previous spectroscopic determinations, which were performed on MT samples containing seven rather than eight metal ions. The protein backbone has a random coil structure with the loops enfolding the copper cluster, which is located in a cleft where it is bound to 10 cysteine residues. The protein structure is somewhat different from that of Ag(7)-MT and similar, but not identical, to that of Cu(7)-MT. Besides the different structure of the metal cluster, the main differences lie in the cysteine topology and in the conformation of some portions of the backbone. The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones.
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{{STRUCTURE_1rju| PDB=1rju | SCENE= }}
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The crystal structure of yeast copper thionein: the solution of a long-lasting enigma.,Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:15613489<ref>PMID:15613489</ref>
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===Crystal structure of a truncated form of yeast copper thionein===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15613489}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1rju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA].
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</StructureSection>
[[Category: Bianco, C Del.]]
[[Category: Bianco, C Del.]]
[[Category: Calderone, V.]]
[[Category: Calderone, V.]]

Revision as of 08:20, 8 October 2014

Crystal structure of a truncated form of yeast copper thionein

1rju, resolution 1.44Å

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