1gwz
From Proteopedia
(New page: 200px<br /> <applet load="1gwz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gwz, resolution 2.50Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GWZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA]]. | + | 1GWZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Site: WPD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: wpd loop]] | [[Category: wpd loop]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:34:19 2007'' |
Revision as of 06:29, 30 October 2007
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Overview
The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic, domain and the complex it forms with the substrate analogue tungstate have, been determined and refined to crystallographic R values of 0.209 at 2.5 A, resolution and 0.207 at 2.8 A resolution, respectively. Despite low, sequence similarity, the catalytic domain of SHP-1 shows high similarity, in secondary and tertiary structures with other protein-tyrosine, phosphatases (PTPs). In contrast to the conformational changes observed in, the crystal structures of PTP1B and Yersinia PTP, the WPD loop, (Trp419-Pro428) in the catalytic domain of SHP-1 moves away from the, substrate binding pocket after binding the tungstate ion. Sequence, alignment and structural analysis suggest that the residues in the WPD, loop, ... [(full description)]
About this Structure
1GWZ is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Hydrolase], with EC number [3.1.3.48]. Structure known Active Site: WPD. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1., Yang J, Liang X, Niu T, Meng W, Zhao Z, Zhou GW, J Biol Chem. 1998 Oct 23;273(43):28199-207. PMID:9774441
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