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1tip

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[[Image:1tip.jpg|left|200px]]<br /><applet load="1tip" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tip.jpg|left|200px]]
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caption="1tip, resolution 2.2&Aring;" />
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'''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''<br />
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{{Structure
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|PDB= 1tip |SIZE=350|CAPTION= <scene name='initialview01'>1tip</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46]
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|GENE= A CODING REGION WHICH COVERS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TIP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=F6P:'>F6P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fructose-2,6-bisphosphate_2-phosphatase Fructose-2,6-bisphosphate 2-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.46 3.1.3.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIP OCA].
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1TIP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIP OCA].
==Reference==
==Reference==
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Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9253407 9253407]
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Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253407 9253407]
[[Category: Fructose-2,6-bisphosphate 2-phosphatase]]
[[Category: Fructose-2,6-bisphosphate 2-phosphatase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:18:53 2008''

Revision as of 12:18, 20 March 2008

Image:1tip.jpg


PDB ID 1tip

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Gene: A CODING REGION WHICH COVERS (Rattus norvegicus)
Activity: Fructose-2,6-bisphosphate 2-phosphatase, with EC number 3.1.3.46
Coordinates: save as pdb, mmCIF, xml



THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE


Overview

The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.

About this Structure

1TIP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407

Page seeded by OCA on Thu Mar 20 14:18:53 2008

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