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1tnd

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[[Image:1tnd.gif|left|200px]]<br /><applet load="1tnd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tnd.gif|left|200px]]
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caption="1tnd, resolution 2.2&Aring;" />
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'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''<br />
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{{Structure
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|PDB= 1tnd |SIZE=350|CAPTION= <scene name='initialview01'>1tnd</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene> and <scene name='pdbligand=GSP:5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CAC:'>CAC</scene> and <scene name='pdbligand=GSP:'>GSP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TND OCA].
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1TND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TND OCA].
==Reference==
==Reference==
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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8259210 8259210]
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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8259210 8259210]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: binding protein(gtp)]]
[[Category: binding protein(gtp)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:15:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:20:43 2008''

Revision as of 12:20, 20 March 2008

Image:1tnd.gif


PDB ID 1tnd

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S


Overview

The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.

About this Structure

1TND is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210

Page seeded by OCA on Thu Mar 20 14:20:43 2008

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