1tnr
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1tnr.gif|left|200px]] | + | [[Image:1tnr.gif|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION''' | + | {{Structure |
| + | |PDB= 1tnr |SIZE=350|CAPTION= <scene name='initialview01'>1tnr</scene>, resolution 2.85Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153440 153440]], Osteopetrosis, autosomal recessive 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602642 602642]], Periodic fever, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191190 191190]] | + | Known diseases associated with this structure: Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153440 153440]], Osteopetrosis, autosomal recessive 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602642 602642]], Periodic fever, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191190 191190]], Psoriatic arthritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153440 153440]] |
==About this Structure== | ==About this Structure== | ||
| - | 1TNR is a [ | + | 1TNR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TNR OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation., Banner DW, D'Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W, Cell. 1993 May 7;73(3):431-45. PMID:[http:// | + | Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation., Banner DW, D'Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W, Cell. 1993 May 7;73(3):431-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8387891 8387891] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 19: | Line 28: | ||
[[Category: complex(lymphokine/receptor)]] | [[Category: complex(lymphokine/receptor)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:20:57 2008'' |
Revision as of 12:20, 20 March 2008
| |||||||
| , resolution 2.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION
Contents |
Overview
The X-ray crystal structure of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined at 2.85 A resolution. The complex has three receptor molecules bound symmetrically to one TNF beta trimer. The receptor fragment, a very elongated end to end assembly of four similar folding domains, binds in the groove between two adjacent TNF beta subunits. The structure of the complex defines the orientation of the ligand with respect to the cell membrane and provides a model for TNF receptor activation. The novel fold of the TNF receptor structure is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole.
Disease
Known diseases associated with this structure: Myocardial infarction, susceptibility to OMIM:[153440], Osteopetrosis, autosomal recessive 2 OMIM:[602642], Periodic fever, familial OMIM:[191190], Psoriatic arthritis, susceptibility to OMIM:[153440]
About this Structure
1TNR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation., Banner DW, D'Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W, Cell. 1993 May 7;73(3):431-45. PMID:8387891
Page seeded by OCA on Thu Mar 20 14:20:57 2008
