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1tou
From Proteopedia
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| - | [[Image:1tou.gif|left|200px]] | + | [[Image:1tou.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand''' | + | {{Structure |
| + | |PDB= 1tou |SIZE=350|CAPTION= <scene name='initialview01'>1tou</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=B1V:2-[(2-OXO-2-PIPERIDIN-1-YLETHYL)SULFANYL]-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL'>B1V</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TOU is a [ | + | 1TOU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOU OCA]. |
==Reference== | ==Reference== | ||
| - | Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:[http:// | + | Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15357970 15357970] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:13 2008'' |
Revision as of 12:21, 20 March 2008
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| , resolution 2.00Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand
Overview
The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
About this Structure
1TOU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970
Page seeded by OCA on Thu Mar 20 14:21:13 2008
Categories: Homo sapiens | Single protein | Axen, E. | Barf, T. | Lundback, T. | Ringom, R. | Rondahl, L. | Uppenberg, J. | B1V | Lipid-binding | Transport
