1ttx
From Proteopedia
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| - | [[Image:1ttx.gif|left|200px]] | + | [[Image:1ttx.gif|left|200px]] |
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| - | '''Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy''' | + | {{Structure |
| + | |PDB= 1ttx |SIZE=350|CAPTION= <scene name='initialview01'>1ttx</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TTX is a [ | + | 1TTX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs., Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A, Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:[http:// | + | Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs., Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A, Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15610002 15610002] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oncomodulin]] | [[Category: oncomodulin]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:23:17 2008'' |
Revision as of 12:23, 20 March 2008
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| Ligands: | |||||||
| Gene: | Homo sapiens (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy
Overview
The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.
About this Structure
1TTX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs., Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A, Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002
Page seeded by OCA on Thu Mar 20 14:23:17 2008
Categories: Homo sapiens | Single protein | Babini, E. | Bertini, I. | Bianco, C Del. | Capozzi, F. | Hollender, D. | Kiss, T. | Luchinat, C. | Quattrone, A. | SPINE, Structural Proteomics in Europe. | CA | Calcium | Ef-hand | Lanthanide | Nmr | Oncomodulin | Spine | Structural genomic | Structural proteomics in europe
