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1wnb

From Proteopedia

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[[Image:1wnb.png|left|200px]]
 
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{{STRUCTURE_1wnb| PDB=1wnb | SCENE= }}
{{STRUCTURE_1wnb| PDB=1wnb | SCENE= }}
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===Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)===
===Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)===
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{{ABSTRACT_PUBMED_15381418}}
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{{ABSTRACT_PUBMED_15381418}}
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==Function==
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[[http://www.uniprot.org/uniprot/ABDH_ECOLI ABDH_ECOLI]] Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.<ref>PMID:16023116</ref> <ref>PMID:15381418</ref>
==About this Structure==
==About this Structure==
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[[1wnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNB OCA].
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[[1wnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNB OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:015381418</ref><references group="xtra"/>
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<ref group="xtra">PMID:015381418</ref><references group="xtra"/><references/>
[[Category: Betaine-aldehyde dehydrogenase]]
[[Category: Betaine-aldehyde dehydrogenase]]
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli k-12]]
[[Category: Cambillau, C.]]
[[Category: Cambillau, C.]]
[[Category: Gruez, A.]]
[[Category: Gruez, A.]]

Revision as of 05:53, 6 November 2013

Template:STRUCTURE 1wnb

Contents

Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)

Template:ABSTRACT PUBMED 15381418

Function

[ABDH_ECOLI] Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.[1] [2]

About this Structure

1wnb is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C. Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase. J Mol Biol. 2004 Oct 8;343(1):29-41. PMID:15381418 doi:10.1016/j.jmb.2004.08.030
  1. ↑ Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR. Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase. FEBS Lett. 2005 Aug 1;579(19):4107-12. PMID:16023116 doi:http://dx.doi.org/S0014-5793(05)00775-1
  2. ↑ Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C. Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase. J Mol Biol. 2004 Oct 8;343(1):29-41. PMID:15381418 doi:10.1016/j.jmb.2004.08.030

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