1txu

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[[Image:1txu.jpg|left|200px]]<br /><applet load="1txu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1txu.jpg|left|200px]]
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caption="1txu, resolution 2.35&Aring;" />
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'''Crystal Structure of the Vps9 Domain of Rabex-5'''<br />
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{{Structure
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|PDB= 1txu |SIZE=350|CAPTION= <scene name='initialview01'>1txu</scene>, resolution 2.35&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE= RABGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of the Vps9 Domain of Rabex-5'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXU OCA].
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1TXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXU OCA].
==Reference==
==Reference==
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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15339665 15339665]
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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15339665 15339665]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: vps9 domain]]
[[Category: vps9 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:24:37 2008''

Revision as of 12:24, 20 March 2008


PDB ID 1txu

Drag the structure with the mouse to rotate
, resolution 2.35Å
Ligands:
Gene: RABGEF1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Vps9 Domain of Rabex-5


Overview

The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that the catalytic core of the Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle. A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases. Conserved exchange determinants map to a common surface of the Vps9 domain, which recognizes invariant aromatic residues in the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.

About this Structure

1TXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:15339665

Page seeded by OCA on Thu Mar 20 14:24:37 2008

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