1ww1

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[[Image:1ww1.png|left|200px]]
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==Crystal structure of tRNase Z from Thermotoga maritima==
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<StructureSection load='1ww1' size='340' side='right' caption='[[1ww1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ww1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WW1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_Z Ribonuclease Z], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.11 3.1.26.11] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ww1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ww1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ww1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ww1 PDBsum], [http://www.topsan.org/Proteins/RSGI/1ww1 TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1ww1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The maturation of the tRNA 3' end is catalyzed by a tRNA 3' processing endoribonuclease named tRNase Z (RNase Z or 3'-tRNase) in eukaryotes, Archaea, and some bacteria. The tRNase Z generally cuts the 3' extra sequence from the precursor tRNA after the discriminator nucleotide. In contrast, Thermotoga maritima tRNase Z cleaves the precursor tRNA precisely after the CCA sequence. In this study, we determined the crystal structure of T. maritima tRNase Z at 2.6-A resolution. The tRNase Z has a four-layer alphabeta/betaalpha sandwich fold, which is classified as a metallo-beta-lactamase fold, and forms a dimer. The active site is located at one edge of the beta-sandwich and is composed of conserved motifs. Based on the structure, we constructed a docking model with the tRNAs that suggests how tRNase Z may recognize the substrate tRNAs.
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{{STRUCTURE_1ww1| PDB=1ww1 | SCENE= }}
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Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.,Ishii R, Minagawa A, Takaku H, Takagi M, Nashimoto M, Yokoyama S J Biol Chem. 2005 Apr 8;280(14):14138-44. Epub 2005 Jan 27. PMID:15701599<ref>PMID:15701599</ref>
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===Crystal structure of tRNase Z from Thermotoga maritima===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15701599}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ww1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW1 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015701599</ref><references group="xtra"/>
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[[Category: Ribonuclease Z]]
[[Category: Ribonuclease Z]]
[[Category: Thermotoga maritima msb8]]
[[Category: Thermotoga maritima msb8]]

Revision as of 18:58, 29 September 2014

Crystal structure of tRNase Z from Thermotoga maritima

1ww1, resolution 2.60Å

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