1tyv

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[[Image:1tyv.gif|left|200px]]<br /><applet load="1tyv" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tyv.gif|left|200px]]
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caption="1tyv, resolution 1.8&Aring;" />
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'''STRUCTURE OF TAILSPIKE-PROTEIN'''<br />
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{{Structure
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|PDB= 1tyv |SIZE=350|CAPTION= <scene name='initialview01'>1tyv</scene>, resolution 1.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= PHAGE P22 GENE 9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=172667 Yersinia phage PY54])
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}}
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'''STRUCTURE OF TAILSPIKE-PROTEIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TYV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_phage_py54 Yersinia phage py54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYV OCA].
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1TYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_phage_py54 Yersinia phage py54]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYV OCA].
==Reference==
==Reference==
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Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8855221 8855221]
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Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8855221 8855221]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Yersinia phage py54]]
[[Category: Yersinia phage py54]]
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[[Category: viral adhesion protein]]
[[Category: viral adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:18:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:25:01 2008''

Revision as of 12:25, 20 March 2008

Image:1tyv.gif


PDB ID 1tyv

Drag the structure with the mouse to rotate
, resolution 1.8Å
Gene: PHAGE P22 GENE 9 (Yersinia phage PY54)
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF TAILSPIKE-PROTEIN


Overview

The O-antigenic repeating units of lipopolysaccharides from Salmonella serogroups A, B, and D1 serve as receptors for the phage P22 tailspike protein, which also has receptor destroying endoglycosidase (endorhamnosidase) activity, integrating the functions of both hemagglutinin and neuraminidase in influenza virus. Crystal structures of the tailspike protein in complex with oligosaccharides, comprising two O-antigenic repeating units from Salmonella typhimurium, Salmonella enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as catalytic residues was identified. Kinetics of binding and cleavage suggest a role of the receptor destroying endorhamnosidase activity primarily for detachment of newly assembled phages.

About this Structure

1TYV is a Single protein structure of sequence from Yersinia phage py54. Full crystallographic information is available from OCA.

Reference

Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors., Steinbacher S, Baxa U, Miller S, Weintraub A, Seckler R, Huber R, Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10584-8. PMID:8855221

Page seeded by OCA on Thu Mar 20 14:25:01 2008

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