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1xok

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[[Image:1xok.png|left|200px]]
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==crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide==
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<StructureSection load='1xok' size='340' side='right' caption='[[1xok]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xok]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XOK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xok RCSB], [http://www.ebi.ac.uk/pdbsum/1xok PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. The crystal structure of an alfalfa mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon interacting. Alternating AUGC residues have opposite orientation, and they base pair in different adjacent duplexes. Localized RNA backbone reversals stabilized by arginine-guanine interactions place the adenosines and guanines in reverse order in the duplex. The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication.
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{{STRUCTURE_1xok| PDB=1xok | SCENE= }}
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Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication.,Guogas LM, Filman DJ, Hogle JM, Gehrke L Science. 2004 Dec 17;306(5704):2108-11. PMID:15604410<ref>PMID:15604410</ref>
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===crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15604410}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1xok]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015604410</ref><references group="xtra"/>
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[[Category: Filman, D J.]]
[[Category: Filman, D J.]]
[[Category: Gehrke, L.]]
[[Category: Gehrke, L.]]

Revision as of 08:26, 8 October 2014

crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide

1xok, resolution 3.00Å

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