1vmp

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[[Image:1vmp.png|left|200px]]
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==STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II==
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<StructureSection load='1vmp' size='340' side='right' caption='[[1vmp]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1vmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VMP FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [http://www.ebi.ac.uk/pdbsum/1vmp PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.
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{{STRUCTURE_1vmp| PDB=1vmp | SCENE= }}
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The solution structure of the anti-HIV chemokine vMIP-II.,Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530<ref>PMID:10595530</ref>
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===STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_10595530}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1vmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:010595530</ref><references group="xtra"/>
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[[Category: Human herpesvirus 8]]
[[Category: Human herpesvirus 8]]
[[Category: Liwang, A C.]]
[[Category: Liwang, A C.]]

Revision as of 19:13, 29 September 2014

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

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