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1ufn

From Proteopedia

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[[Image:1ufn.png|left|200px]]
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==Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20Rik)==
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<StructureSection load='1ufn' size='340' side='right' caption='[[1ufn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{STRUCTURE_1ufn| PDB=1ufn | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ufn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UFN FirstGlance]. <br>
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===Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20Rik)===
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 5830484A20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ufn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ufn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ufn RCSB], [http://www.ebi.ac.uk/pdbsum/1ufn PDBsum], [http://www.topsan.org/Proteins/RSGI/1ufn TOPSAN]</span></td></tr>
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<table>
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==About this Structure==
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== Disease ==
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[[1ufn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UFN OCA].
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[[http://www.uniprot.org/uniprot/SP110_MOUSE SP110_MOUSE]] Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis.<ref>PMID:15815631</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/SP110_MOUSE SP110_MOUSE]] May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells.<ref>PMID:15815631</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1ufn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Aoki, M.]]
[[Category: Aoki, M.]]

Revision as of 21:09, 29 September 2014

Solution structure of the SAND domain of the putative nuclear protein homolog (5830484A20Rik)

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