1u5w
From Proteopedia
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| - | [[Image:1u5w.gif|left|200px]] | + | [[Image:1u5w.gif|left|200px]] |
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| - | '''Crystal structure of hypothetical protein yjjX from Escherichia coli''' | + | {{Structure |
| + | |PDB= 1u5w |SIZE=350|CAPTION= <scene name='initialview01'>1u5w</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= yjjX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of hypothetical protein yjjX from Escherichia coli''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1U5W is a [ | + | 1U5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5W OCA]. |
==Reference== | ==Reference== | ||
| - | Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis., Zheng J, Singh VK, Jia Z, Structure. 2005 Oct;13(10):1511-20. PMID:[http:// | + | Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis., Zheng J, Singh VK, Jia Z, Structure. 2005 Oct;13(10):1511-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16216582 16216582] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: bsgi]] | [[Category: bsgi]] | ||
[[Category: montreal-kingston bacterial structural genomics initiative]] | [[Category: montreal-kingston bacterial structural genomics initiative]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:27:40 2008'' |
Revision as of 12:27, 20 March 2008
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| , resolution 2.3Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | yjjX (Escherichia coli) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of hypothetical protein yjjX from Escherichia coli
Overview
Inosine triphosphate (ITP) and xanthosine triphosphate (XTP) are formed upon deamination of ATP and GTP as a result of exposure to chemical mutagens and oxidative damage. Nucleic acid synthesis requires safeguard mechanisms to minimize undesired lethal incorporation of ITP and XTP. Here, we present the crystal structure of YjjX, a protein of hitherto unknown function. The three-dimensional fold of YjjX is similar to those of Mj0226 from Methanococcus janschii, which possesses nucleotidase activity, and of Maf from Bacillus subtilis, which can bind nucleotides. Biochemical analyses of YjjX revealed it to exhibit specific phosphatase activity for inosine and xanthosine triphosphates and have a possible interaction with elongation factor Tu. The enzymatic activity of YjjX as an inosine/xanthosine triphosphatase provides evidence for a plausible protection mechanism by clearing the noncanonical nucleotides from the cell during oxidative stress in E. coli.
About this Structure
1U5W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis., Zheng J, Singh VK, Jia Z, Structure. 2005 Oct;13(10):1511-20. PMID:16216582
Page seeded by OCA on Thu Mar 20 14:27:40 2008
