1u8c

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[[Image:1u8c.jpg|left|200px]]<br /><applet load="1u8c" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1u8c.jpg|left|200px]]
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caption="1u8c, resolution 3.1&Aring;" />
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'''A novel adaptation of the integrin PSI domain revealed from its crystal structure'''<br />
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{{Structure
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|PDB= 1u8c |SIZE=350|CAPTION= <scene name='initialview01'>1u8c</scene>, resolution 3.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= ITGAV, VNRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ITGB3, GP3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''A novel adaptation of the integrin PSI domain revealed from its crystal structure'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1U8C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8C OCA].
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1U8C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U8C OCA].
==Reference==
==Reference==
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A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299032 15299032]
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A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299032 15299032]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: vitronectrin receptor]]
[[Category: vitronectrin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:21:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:28:38 2008''

Revision as of 12:28, 20 March 2008

Image:1u8c.jpg


PDB ID 1u8c

Drag the structure with the mouse to rotate
, resolution 3.1Å
Ligands: , and
Gene: ITGAV, VNRA (Homo sapiens), ITGB3, GP3A (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



A novel adaptation of the integrin PSI domain revealed from its crystal structure


Contents

Overview

Integrin beta-subunits contain an N-terminal PSI (for plexin-semaphorin-integrin) domain that contributes to integrin activation and harbors the PI(A) alloantigen associated with immune thrombocytopenias and susceptibility to sudden cardiac death. Here we report the crystal structure of PSI in the context of the crystallized alphaVbeta3 ectodomain. The integrin PSI forms a two-stranded antiparallel beta-sheet flanked by two short helices; its long interstrand loop houses Pl(A) and may face the EGF2 domain. The integrin PSI contains four cysteine pairs connected in a 1-4, 2-8, 3-6, 5-7 pattern. An unexpected feature of the structure is that the final, eighth cysteine is located C-terminal to the Ig-like hybrid domain and is thus separated by the hybrid domain from the other seven cysteines of PSI. This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation.

Disease

Known diseases associated with this structure: Glanzmann thrombasthenia, type B OMIM:[173470]

About this Structure

1U8C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel adaptation of the integrin PSI domain revealed from its crystal structure., Xiong JP, Stehle T, Goodman SL, Arnaout MA, J Biol Chem. 2004 Sep 24;279(39):40252-4. Epub 2004 Aug 6. PMID:15299032

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