1tg8

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[[Image:1tg8.png|left|200px]]
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==The structure of Dengue virus E glycoprotein==
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<StructureSection load='1tg8' size='340' side='right' caption='[[1tg8]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TG8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tge|1tge]], [[1thd|1thd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg8 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
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{{STRUCTURE_1tg8| PDB=1tg8 | SCENE= }}
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Conformational changes of the flavivirus E glycoprotein.,Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG Structure. 2004 Sep;12(9):1607-18. PMID:15341726<ref>PMID:15341726</ref>
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===The structure of Dengue virus E glycoprotein===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15341726}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1tg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015341726</ref><references group="xtra"/>
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Baker, T S.]]
[[Category: Baker, T S.]]

Revision as of 08:19, 8 October 2014

The structure of Dengue virus E glycoprotein

1tg8, resolution 2.61Å

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