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1xwy
From Proteopedia
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{{STRUCTURE_1xwy| PDB=1xwy | SCENE= }} | {{STRUCTURE_1xwy| PDB=1xwy | SCENE= }} | ||
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===Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution=== | ===Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TATD_ECOLI TATD_ECOLI]] Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Although TatD is not required for export activity, it is a central component of a quality control system that is linked to the Tat translocation system. May act by degrading wild-type pre-protein molecules that are misfolded. Shows magnesium-dependent DNase activity.<ref>PMID:10747959</ref> <ref>PMID:19343049</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[1xwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWY OCA]. | [[1xwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWY OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Almo, S C.]] | [[Category: Almo, S C.]] | ||
Revision as of 06:40, 2 May 2013
Contents |
Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution
Function
[TATD_ECOLI] Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Although TatD is not required for export activity, it is a central component of a quality control system that is linked to the Tat translocation system. May act by degrading wild-type pre-protein molecules that are misfolded. Shows magnesium-dependent DNase activity.[1] [2]
About this Structure
1xwy is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- ↑ Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T. TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. J Biol Chem. 2000 Jun 2;275(22):16717-22. PMID:10747959 doi:10.1074/jbc.M000800200
- ↑ Matos CF, Di Cola A, Robinson C. TatD is a central component of a Tat translocon-initiated quality control system for exported FeS proteins in Escherichia coli. EMBO Rep. 2009 May;10(5):474-9. doi: 10.1038/embor.2009.34. Epub 2009 Apr 3. PMID:19343049 doi:10.1038/embor.2009.34
Categories: Escherichia coli | Almo, S C. | Burley, S K. | Malashkevich, V N. | NYSGXRC, New York SGX Research Center for Structural Genomics. | Raushel, F M. | Xiang, D F. | Deoxyribonuclease | Hydrolase | New york sgx research center for structural genomic | Nysgxrc | Protein structure initiative | Psi | Structural genomic | Tatd | Tim barrael | Zinc ion
